Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
Senolytic Peptide
FOXO4-DRI
- FOXO4 D-Retro-Inverso Proxofim
A 46-residue peptide built entirely from D-amino acids in retro-inverso orientation, comprising a FOXO4-derived segment joined to an arginine/lysine-rich cell-penetrating sequence.
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Compound information
Technical specifications
Description
A 46-residue peptide built entirely from D-amino acids in retro-inverso orientation, comprising a FOXO4-derived segment joined to an arginine/lysine-rich cell-penetrating sequence.
Molecular profile
- Type
- All-D retro-inverso peptide
- Molecular weight
- 5358.1 g/mol
- Molecular formula
- C228H388N86O64
- Amino acids
- 46
Storage requirements
Lyophilized (powder)
-20°C
Reconstituted
2-8°C
- Protect from light
- Avoid repeated freeze-thaw cycles
- Reconstitute with bacteriostatic water
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Sources & references
Published literature, listed for reference only. Nothing here describes an intended use of this product.
Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes
Front Bioeng Biotechnol 2021
View sourceThe disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI
Nat Commun 2025
View sourceImportant research notice
Not for human consumption. This product is sold exclusively for laboratory research. It is not intended to diagnose, treat, cure, or prevent any disease, and has not been evaluated by the U.S. Food and Drug Administration.
Any literature referenced on this page is provided for bibliographic reference only. It is not a description of this product, nor a claim about what it does.
By purchasing you confirm you are a qualified researcher and will handle this material in accordance with all applicable laws and institutional requirements.
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