Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase
NNMT Inhibitor
5-Amino-1MQ
- 5-amino-1-methylquinolinium 5A1MQ
A synthetic quaternary quinolinium small molecule, the 5-amino derivative of 1-methylquinolinium. Studied as a cell-permeable inhibitor of nicotinamide N-methyltransferase.
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Compound information
Technical specifications
Description
A synthetic quaternary quinolinium small molecule, the 5-amino derivative of 1-methylquinolinium. Studied as a cell-permeable inhibitor of nicotinamide N-methyltransferase.
Molecular profile
- Type
- Synthetic small-molecule NNMT inhibitor
- CAS number
- 42464-96-0 (iodide salt)
- Molecular weight
- 286.11 g/mol (iodide salt)
- Molecular formula
- C10H11IN2
Storage requirements
Lyophilized (powder)
-20°C
Reconstituted
2-8°C
- Protect from light
- Avoid repeated freeze-thaw cycles
- Reconstitute with bacteriostatic water
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Sources & references
Published literature, listed for reference only. Nothing here describes an intended use of this product.
Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice
Biochem Pharmacol 2018
View sourceSmall molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells
Biochem Pharmacol 2019
View sourceImportant research notice
Not for human consumption. This product is sold exclusively for laboratory research. It is not intended to diagnose, treat, cure, or prevent any disease, and has not been evaluated by the U.S. Food and Drug Administration.
Any literature referenced on this page is provided for bibliographic reference only. It is not a description of this product, nor a claim about what it does.
By purchasing you confirm you are a qualified researcher and will handle this material in accordance with all applicable laws and institutional requirements.
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