LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist: From discovery to clinical proof of concept
Triple Receptor Agonist
GLP-3 (RT)
- LY3437943
A synthetic 39-amino-acid peptide built on a GIP-based backbone with non-natural amino acid substitutions and a C20 fatty diacid conjugated via a linker. Studied as a triple agonist at the GIP, GLP-1 and glucagon receptors.
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Technical specifications
Description
A synthetic 39-amino-acid peptide built on a GIP-based backbone with non-natural amino acid substitutions and a C20 fatty diacid conjugated via a linker. Studied as a triple agonist at the GIP, GLP-1 and glucagon receptors.
Molecular profile
- Type
- Triple GIP/GLP-1/glucagon receptor agonist peptide
- CAS number
- 2381089-83-2
- Molecular weight
- 4731.34 g/mol
- Molecular formula
- C221H342N46O68
- Amino acids
- 39
Storage requirements
- Protect from light
- Avoid repeated freeze-thaw cycles
- Reconstitute with bacteriostatic water
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Sources & references
Published literature, listed for reference only. Nothing here describes an intended use of this product.
Differentiation of human subcutaneous adipocytes and measurement of lipolytic function induced by GIP or LY3437943
STAR Protoc 2023
View sourceComparison of the effects of Liraglutide, Tirzepatide, and Retatrutide on diabetic kidney disease in db/db mice
Endocrine 2025
View sourceImportant research notice
Not for human consumption. This product is sold exclusively for laboratory research. It is not intended to diagnose, treat, cure, or prevent any disease, and has not been evaluated by the U.S. Food and Drug Administration.
Any literature referenced on this page is provided for bibliographic reference only. It is not a description of this product, nor a claim about what it does.
By purchasing you confirm you are a qualified researcher and will handle this material in accordance with all applicable laws and institutional requirements.
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