Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide
GLP-1 Receptor Agonist
GLP-2 (SM)
- NN9535 NNC 0113-0217
A synthetic 31-amino-acid analogue of human GLP-1 with Aib substituted at position 8 and Arg at position 34, acylated at Lys26 with a C18 fatty diacid via a linker. Studied as a GLP-1 receptor agonist.
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Compound information
Technical specifications
Description
A synthetic 31-amino-acid analogue of human GLP-1 with Aib substituted at position 8 and Arg at position 34, acylated at Lys26 with a C18 fatty diacid via a linker. Studied as a GLP-1 receptor agonist.
Molecular profile
- Type
- GLP-1 receptor agonist peptide
- CAS number
- 910463-68-2
- Molecular weight
- 4113.58 g/mol
- Molecular formula
- C187H291N45O59
- Amino acids
- 31
Storage requirements
Lyophilized (powder)
-20°C
Reconstituted
2-8°C
- Protect from light
- Avoid repeated freeze-thaw cycles
- Reconstitute with bacteriostatic water
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Sources & references
Published literature, listed for reference only. Nothing here describes an intended use of this product.
Semaglutide lowers body weight in rodents via distributed neural pathways
JCI Insight 2020
View sourceThe GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE(-/-) and LDLr(-/-) Mice
JACC Basic Transl Sci 2018
View sourceImportant research notice
Not for human consumption. This product is sold exclusively for laboratory research. It is not intended to diagnose, treat, cure, or prevent any disease, and has not been evaluated by the U.S. Food and Drug Administration.
Any literature referenced on this page is provided for bibliographic reference only. It is not a description of this product, nor a claim about what it does.
By purchasing you confirm you are a qualified researcher and will handle this material in accordance with all applicable laws and institutional requirements.
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